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- Bioprocess SolutionsBioprocess Solutions
Process analysers as inline and online measurement technologies provide real-time data for outstanding process control, which results in high-quality production. Thorough monitoring by process analysers with up to 100% coverage of process parameters and subsequent documentation ensures optimal compliance. Moreover, monitoring makes transactions verifiable and establishes a basis of trust between suppliers and customers.
The probe operates on a transmittance principle using IR light to track total biomass. It is a tool to increase microbial fermentation yield by maximizing the use of nutrients, gases and other critical parameters. The system reduces the cost associated with 24-hour sampling and removes inconsistent off-line analysis. The BioPAT® Fundalux comes integrated into our BioPAT® DCU and automatic data conversion to optical density can be achieved with BioPAT® MFCS.
BioPAT® Spectro NIR process sensor monitors the fermentation process inline by providing real-time feedback. Monitoring the process values during biotechnological fermentation is crucial for maintaining the high efficiency and quality of a bioprocess. Although commercial sensor systems are available for real-time monitoring of some variables, such as pH or the concentration of dissolved oxygen, BioPAT® Spectro provides monitoring capabilities that are light years beyond such sensor systems.
BioPAT® Trace is an analysis system for simultaneous online monitoring of glucose and lactate in laboratory and industrial cultivations of microorganisms and cell lines. BioPAT® Trace ensures a high degree of measurement performance and process reliability due to its unique combination of a reusable analyser and single-use enzymatic sensors and fluidic elements.
Automated Biomass Measurement Using BioPAT® ViaMass BioPAT®
ViaMass is a system for measuring viable biomass in cell culture processes. Unlike known reference methods, this system is completely integrated into single-use bioreactors. It determines the biomass directly in line, reducing the need for manual sampling. Integrated into the bioreactor’s DCU control system, BioPAT® ViaMass permits automatic monitoring and control of viable biomass.
- Reduces the need for manual sampling
- Real-time measurement of and feedback on viable biomass
- Ensures batch-to-batch consistency
- Eliminates operator influence that occurs in manual biomass measurements
Manufactured under the Licence of Hamilton.
The BioPAT® Xgas monitors and controls bioprocesses in real time. It is a combined oxygen-carbon dioxide sensor featuring automatic compensation of humidity and pressure. The range for oxygen is 1 - 50% and for carbon dioxide 0 - 10%, with ±3% accuracy on the reference value and a difference of less than ±0.2% on the reading. The sensor is non-invasive and can be conveniently integrated onto a new Sartorius Stedim bioreactor exhaust line or your current system.
Process Analytical Technology (PAT)
Process Analytical Technology (PAT) is much more than just one sensor integrated into a process. It is a risk-based strategy for designing, analysing and controlling manufacturing processes. PAT offers a number of tools for measuring and controlling critical process parameters. Discover more about Process Analytical Technology on our PAT microsite.